What diseases does Penoxycyline prevent in RimWorld?

In the local 1.6.4633 PenoxycylineHigh hediff, the makeImmuneTo list contains only Malaria, SleepingSickness, and Plague.

Why did my pawn get flu after taking Penoxycyline?

Because flu is not in the local Penoxycyline immunity list. Penoxycyline only blocks new Malaria, Sleeping sickness, and Plague infections.

How long does Penoxycyline last in RimWorld?

The local build applies severity 1.0 and decays it at -0.18 per day, which yields about 5.56 in-game days of coverage. Scheduling every 5 days avoids gaps.

Does Penoxycyline have addiction or real overdose risk?

The local Penoxycyline def has no addiction, tolerance, or chemical need fields. It does have an overdose severity offset of 0.08 to 0.14 per dose, but a visible minor overdose starts at 0.50, so a normal scheduled dose is far below that threshold.

RimWorld Penoxycyline Tool (1.6.4633) | Schedule, Biome Risk & Caravan Planner

Installed RimWorld Build 1.6.4633 Rev1266

RimWorld Penoxycyline Defense Protocol & Optimization Tool

Fast answer: Penoxycyline is a preventive medical drug. In your local game files it blocks only Malaria, Sleeping sickness, and Plague, lasts about 5.56 days, and costs 2 Neutroamine per dose. Use it colony-wide in jungle biomes, keep it targeted in moderate biomes, and default to reserve-only in low-disease maps.

Local Penoxycyline.xml values Caravan disease target tags verified Trader Neutroamine ranges included

Every 5 Days Safe schedule from the local -0.18/day decay.

2 Neutroamine Per dose at the DrugLab after PenoxycylineProduction.

Caravan Safe Disease incidents in local defs can target Caravan as well as player maps.

Command Board

Cost-Benefit Analysis & Biome Strategy

Advanced Logistics & Caravan Checklist

Penoxycyline workflow and mod spotlight card

Use the board above for fast section jumps. The tools below update live from your inputs.

Quick Deploy: Build a Set-and-Forget Policy

Choose the biome, storyteller, colony pressure, and protected headcount once. The page will output a practical policy template and a recommendation band.

Biome

Storyteller

Punishment Level

Coverage Mode

Protected pawns

Policy namePENOXY-CYCLE

ScheduleEvery 5 days

Allowed for joyNo

Take to inventory1

Best scopeDoctors, new recruits, and caravan pawns

WhyTemperate forest still rolls malaria and plague, but colony-wide dosing is usually not necessary unless the colony is fragile.

Situational

Local evidence: the built-in example policy in DrugPolicyDefs.xml uses daysFrequency and takeToInventory. This page simply maps those same knobs onto Penoxycyline.

Med-Scan Data Card

The exact values below come from the installed Core defs on this machine.

5.56 daysCoverage window from severity 1.0 decaying at -0.18/day.

2 NeutroamineCraft cost per dose at the drug lab.

600 workWorkToMake on the local thing def.

18 silverMarket value per dose if you buy instead of craft.

Research: 500PenoxycylineProduction after DrugProduction.

Randy: day 0Randy has no disease grace period; Cassandra starts at day 9 and Phoebe at day 12.

Prevents

Malaria
Sleeping sickness
Plague

Does Not Prevent

Flu
Gut worms
Muscle parasites
Fibrous or sensory mechanites
Organ decay

Penoxycyline only blocks new infections. If a pawn was already infected, even by an undiscovered disease, the active high does nothing to cure it.

Cost-Benefit Analysis & Biome Strategy

The recommendation below combines the local biome disease pools with the settings you chose above. The disease pool is code-backed; the final tag is a practical planning layer.

Penoxycyline worth-it matrix preview — Jungle and swamp biomes push Penoxycyline toward colony-wide use. Lower-disease maps pull it back toward reserve or specialist coverage.

Situational

Temperate forest blocks malaria and plague but still leaves flu, gut worms, and mechanites in the pool, so Penoxycyline is usually best on doctors, new recruits, or caravan pawns instead of everyone.

Temperate forest Cassandra Classic Strive to Survive Doctors / recruits

Weighted share of the local human disease pool blocked in the selected biome.

50d Biome disease mean time between pulls before storyteller randomness.

48 Estimated annual doses for the protected pawn count at one dose every 5 days.

96 Neutroamine needed per 60-day RimWorld year.

Difficulty on this page does not imply a hidden disease multiplier in Core data. It only raises the planning priority because a disease event hurts more when margins are thinner.

Troubleshooting & Myths

Most Penoxycyline confusion comes from expecting it to cure infections or stop diseases that are not actually in the immunity list.

Penoxycyline troubleshooting panel preview — The local answer is simple: check the immunity list, then check whether the dose was active before the infection roll happened.

"I gave it to them, but they still got the flu."

That is expected. The local makeImmuneTo list contains only Malaria, Sleeping sickness, and Plague. Flu is outside the protected list.

Use Penoxycyline for disease-map prevention, not as a blanket anti-sickness button.

"They took it, but still got malaria."

Two common causes: the pawn already had a hidden infection before the dose, or the high had expired. The local description explicitly says it prevents only new infections and does not cure existing ones, even undiscovered ones.

Run the policy every 5 days, not every 6, and keep travel pawns carrying 1 dose so the timer does not drift while moving.

"Does it have addiction or a real overdose chance?"

The local Penoxycyline thing def has no addiction hediff, no tolerance hediff, and no chemical need. It is not coded like psychite, wake-up, beer, or go-juice.

It does add 0.08~0.14 overdose severity per dose, but a visible minor overdose begins at 0.50. A standard scheduled dose is far below that threshold.

"Should caravans really take it?"

Yes, when the route crosses real disease biomes. Local disease incidents include the Caravan target tag, so travel does not make you immune to malaria or plague rolls.

Short routes in desert, tundra, or sea ice are usually reserve-only. Jungle and swamp trips deserve deliberate packing.

Penoxycyline overdose math
per dose = +0.08 to +0.14 overdose severity
visible minor overdose = 0.50
major overdose = 0.75
lethal severity = 1.00

4 fast doses = 0.32 to 0.56
1 scheduled dose every 5 days = practical non-issue

Advanced Logistics & Caravan Checklist

Use the travel-day rule from the poster card, then convert it into total doses, weight, and Neutroamine cost.

Penoxycyline caravan checklist preview — Baseline rule: **ceil(days of travel / 5)** doses per pawn, then add at least one spare stack for the whole caravan.

Travel days

Caravan pawns

Spare doses

9 Total doses to pack.

2 Doses per pawn from the travel window.

0.045 kg Total mass at 0.005 each.

18 Neutroamine required if you craft instead of buy.

For a 9-day run, each pawn wants 2 doses. One spare stack keeps a missed timing tick from turning into a malaria gap mid-route.

Sourcing & Workflow

Keep this simple: buy Neutroamine in bulk, synthesize Penoxycyline when the disease pressure justifies it, and let policy carry do the rest.

Penoxycyline workflow spotlight preview — Vanilla policy handles the schedule. Workflow mods help with carrying and doctor/hauler priorities, but they do not change the core immunity list unless they patch defs.

Craft pathPenoxycylineProduction → DrugLab → 2 Neutroamine

Buy in bulkOutlanders and orbitals are the reliable Neutroamine engine.

Vanilla firstSchedule via Assign. Keep inventory carry for travel or jungle coverage.

Source	Local Range	Best Use
Outlander settlement	50-200	Steady reserve building between caravans.
Outlander bulk caravan	70-160	Mid-game map-side refill.
Orbital bulk goods	100-200	Reliable colony-wide Penoxy supply.
Orbital exotic goods	100-500	Best big spike when jungle dosing the whole colony.
Orbital pirate merchant	100-400	Backup source if you do not mind the trader category.
Tribal bulk caravan	25-100	Early refill if outlanders are absent.

If you only need one recommendation: tropical rainforest and tropical swamp justify colony-wide Penoxycyline far more often than temperate forest does. In desert, tundra, underground, and ice maps, keep a reserve and spend the Neutroamine elsewhere first.

Local File References

These are the installed files this page is anchored to. Use them when you want to verify the behavior against your own copy of RimWorld.

Penoxycyline Core Def

/game/Data/Core/Defs/Drugs/Penoxycyline.xml
Drug category, research gate, 2 Neutroamine cost, 600 work, overdose severity, and the makeImmuneTo list.

Research Gate

/game/Data/Core/Defs/ResearchProjectDefs/ResearchProjects_1.xml
PenoxycylineProduction costs 500 research after DrugProduction.

Biome Disease Pools

/game/Data/Core/Defs/BiomeDefs/Biomes_Warm.xml, Biomes_Temperate.xml, Biomes_WarmArid.xml, Biomes_Cold.xml, Biomes_Misc.xml
Disease mean-time-between values and commonality weights.

Caravan Disease Targeting

/game/Data/Core/Defs/Storyteller/Incidents_Map_Disease.xml
Disease incidents target Map_PlayerHome and Caravan.

Storyteller Grace Windows

/game/Data/Core/Defs/Storyteller/Storytellers.xml
Cassandra diseases begin after day 9, Phoebe after day 12, Randy at day 0.

Policy and Trader Support

/game/Data/Core/Defs/DrugPolicyDefs/DrugPolicyDefs.xml and local TraderKindDefs
These files back the schedule/inventory pattern and the Neutroamine stock table.